Abstract：Living cells rely on the self-organization mechanisms of cytoskeleton to adapt to their requirements. In processes such as cell division, or cellular motility rely on the controlled self-assembly and disassembly of well defined active cytoskeletal structures interacting with lipid membranes. One important and promising strategy to identify the underlying governing principles is to quantify the underlying physical processes in model systems mimicking functional units of living cell. In previous lectures I showed how density variations lead to the emergence of order in high density motility assay, introducing the concept of active matter. Here I will introduce a active microtubule system, confined into vesicles. The activity induced shape deformations are analyzed and the resulting power spectra computed. While bending dominated modes are observable, also footprints of active transport can be identified in the spectra.

Bio: Prof. Bausch holds currently the Chair of Cellular Biophysics and is the Founding Director of the Center of Protein Assemblies at the Technical University of Munich. Since 2022 he is founding director of the Center of Organoid Systems and Tissue Engineering at the TUM. After studying physics at TUM and the Université de Montréal, he received his doctorate at TUM (1999). An Emmy Noether scholarship enabled him to study at Harvard University under Prof. D. Weitz. After receiving many invitations from around the world, Prof. Bausch accepted the Chair of Cellular Biophysics at TUM in 2008. He had a visiting Miller Professor Appointment at the University of California, Berkeley (2015) and since 2021 he is a visiting Scholar at Harvard University. His work targets a quantitative understanding of the mechanical properties of the cytoskeleton, and the microscopic mechanisms of self-organization on the molecular as well on the organoid scale, to which end he developed a range of active matter systems.