leshimin@xmu.edu.cn
ROOM 221
Website: https://orcid.org/0000-0003-2359-1897
Research AreasMechanobiology, Single-molecule Mechanical Manipulation, Magnetic Tweezers, Protein-Protein Interactions, Nucleic Acid -Protein Interactions
Education&Work Experience
2022.10 -- now：Xiamen University, Department of Physics，Professor
2022.04- 2022.09：Xiamen University, Department of Physics，Associate Professor
2016.02-2022.02: National University of Singapore, Department of Physics, Research Fellow
2010.08-2015.10: National University of Singapore, Mechanobiology Institute, PhD
2006.09-2010.07: Xiamen University, Department of Physics, Bachelor of Science
Publications
1.M. Yu#, S. Le#, S. Barnett#, Z. Guo, X. Zhong, P. Kanchanawong*, and J. Yan*, Implementing Optogenetic Modulation in Mechanotransduction. Physical Review X, 10, 021001 (2020).
2.S. Le#, M. Yu#, and J. Yan*, Direct Single-molecule Quantification Reveals Surprisingly High Mechanical Stability of Vinculin--talin/-catenin Linkages. Science Advances, 5 (12), eaav2720 (2019).
3.S. Le#, M. Yu#, and J. Yan*, Phosphorylation Reduces the Mechanical Stability of -catenin/-catenin Complex. Angewandte Chemie, 58(51) 18663-18669 (2019).
4.S. Le, X. Hu, M. Yao, H. Chen, M. Yu, X. Xu, F. Margadant, M. Sheetz*, and J. Yan*, Mechanotransmission and Mechanosensing of Human -actinin 1, Cell Reports., 21, 1-10. (2017).
5.S. Le, H. Chen, X. Zhang, J. Chen, K. Patil, K. Muniyappa*, and J. Yan*, Mechanical Force Antagonizes the Inhibitory Effects of RecX on RecA Filaments Formation in M. tuberculosis. Nucleic Acids Research 42 (19): 11992-11999. (2014).
Other
Lab（实验室房间号）: 220
