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SHUAI Jianwei

Professor

jianweishuai@xmu.edu.cn

Room 354

Website: /index.php/shuaiweb

Research AreasCellular signaling networks, calcium signaling, neural networks, protein molecular dynamics, cancer dynamics, immune dynamics, big data in healthcare, deep learning

Education&Work Experience
2007.7- present   Professor  Department of Physics Xiamen University, China
2004.1- 2007.6    Assistant Project Scientist Dept of Neurobiology and Behavior University of California, Irvine,  CA, USA
2006.3- 2006.5    Visiting Scientist Hahn-Meitner Institute, Berlin, Germany Department of theoretical Physics
2001.1-2003.12   Research Associate Department of Physics and Astronomy Ohio University,  Athens, OH,  USA
1998.5-2000.12   Research Associate Department of Biomedical Engineering Case Western Reserve University, Cleveland, OH, USA
1997.7-1998.3     Research Associate Department of Applied Physics and Chemistry Univ of Electro-Communications,Tokyo,Japan
1996.11-1997.6   Research Assistant Department of Electronic Engineering City University of Hong Kong,  Hong Kong
1995.6-1996.10   Lecturer Department of Physics Xiamen University, Xiamen, China
1995   Ph.D.  Department of Physics,  Xiamen University, Xiamen, China
1992  M.S.    Department of Physics,  Xiamen University, Xiamen, China
1989   B. A.   Department of Physics,  Xiamen University, Xiamen, China
Publications
1. C Lv, F Li, X Li, Y Tian, Y Zhang, X Sheng, Y Song, Q Meng, S Yuan, L Luan, T Andl, X Feng, B Jiao, M Xu, M Plikus, X Dai, C Lengner, W Cui, F Ren, JW Shuai, S Millar, and Z Yu. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nature Communications,2017, 8: 1036
2. Y Tian, X Ma, C Lv, X Sheng, X Li, R Zhao, Y Song, T Andl, M Plikus, J Sun, F Ren, JW Shuai, C Lengner, W Cui, Z Yu. Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis. ELife. 2017, 6: e29538.
3. Yuan Chen, Hong Qi, Xiang Li, Meichun Cai, Xingqiang Chen, Wen Liu, and Jianwei Shuai. Suppressing effect of Ca2+ blips on puff amplitudes by inhibiting channels to prevent recovery. Phys. Rev. E 2016, 94: 022411
4. Xing-Xing Wu and Jianwei Shuai*, Effects of extracellular potassium diffusion on electrically coupled neuron networks, Physical Review E 91(2015) 022712
5. Hong Qi, Linxi Li and Jianwei Shuai, Optimal microdomain corsstalk between endoplasmic reticulum and mitochondria for Ca2+ oscillations, Scientific Reports 5 (2015) 7984 1-11
6. S Ruediger, P Jung and JW Shuai. Termination of Ca2+ release for clustered IP3R channels. PLoS Computational Biology 8 (2012) e1002485 1-13
7. S Rüdiger, J W Shuai* and IM Sokolov. Law of mass action, detailed balance, and the modeling of calcium puffs. Physical Review Letters, 105 (2010) 048103 1-4
8. J W Shuai and P Jung. Entropically enhanced excitability in small systems. Physical Review Letters, 95: 114501 1-4 (2005)
9. J W Shuai and P Jung. Optimal ion channel clustering for intracellular calcium signaling. Proceedings of the National Academy of Sciences of USA, 100: 506-510 (2003)
10. J W Shuai and P Jung. Optimal Intracellular Calcium Signaling. Physical Review Letters, 88: 68102 1-4 (2002)
Funds&Project
(1)XMU Mingjiang Distinguished Professor Foundation of Fujian Province  
        Computing biophysics  
(2007 – 2010)  
(2)The National Natural Science Foundation of China  
The stochastic dynamics of multiple calcium signal  
NSFC 10775114  
(2008 – 2010)  
(3)The Science and Technology Foundation of Ministry of Education of China  
Simulation of intercellular calcium waves in glia cells  
CME Key grant 108075  
(2008 – 2010)  
(4)National Institutes of Health  Foundation of USA (Co-PI)  
Multi-scale observation and modelling of IP3/Ca signalling  
Grant No.:2R0lGM065830-06A1  
PI: John E. Pearson, Los Alamos Nat Lab  
Co-PI: Ian Parker, University of California, Irvine  
           Kevin Foskett, University of Pennsylvania  
           Don-On Daniel Mak, University of Pennsylvania  
           Jianwei Shuai, Xiamen University  
NIH GM65830  
(2009-2012)  
(5)The National Natural Science Foundation of China  
The interaction between neuronal action potential and intracellular calcium signal  
NSFC 30970970  
(2010 – 2012)  
(6)Specialized Research Fund for the Doctoral Program of Higher Education  
Modelling of calcium diffusion in cellular nanotube  
SRFDP 20090121110028  
(2010 – 2012)  
(7)China National Funds for Distinguished Young Scientists  
Computing Biophysics  
(2012-2015)  
(8)The Funds for the Leading Talents of Fujian Province  
(2013-2015)
Courses
Introduction of Biophysics
姓名 SHUAI Jianwei 职称职务 Professor
邮箱 jianweishuai@xmu.edu.cn 办公室 Room 354
电话 个人主页 /index.php/shuaiweb
其他信息 研究方向岗位职责 Cellular signaling networks, calcium signaling, neural networks, protein molecular dynamics, cancer dynamics, immune dynamics, big data in healthcare, deep learning
教育和工作经历 2007.7- present   Professor  Department of Physics Xiamen University, China
2004.1- 2007.6    Assistant Project Scientist Dept of Neurobiology and Behavior University of California, Irvine,  CA, USA
2006.3- 2006.5    Visiting Scientist Hahn-Meitner Institute, Berlin, Germany Department of theoretical Physics
2001.1-2003.12   Research Associate Department of Physics and Astronomy Ohio University,  Athens, OH,  USA
1998.5-2000.12   Research Associate Department of Biomedical Engineering Case Western Reserve University, Cleveland, OH, USA
1997.7-1998.3     Research Associate Department of Applied Physics and Chemistry Univ of Electro-Communications,Tokyo,Japan
1996.11-1997.6   Research Assistant Department of Electronic Engineering City University of Hong Kong,  Hong Kong
1995.6-1996.10   Lecturer Department of Physics Xiamen University, Xiamen, China
1995   Ph.D.  Department of Physics,  Xiamen University, Xiamen, China
1992  M.S.    Department of Physics,  Xiamen University, Xiamen, China
1989   B. A.   Department of Physics,  Xiamen University, Xiamen, China
代表性文章或专著 1. C Lv, F Li, X Li, Y Tian, Y Zhang, X Sheng, Y Song, Q Meng, S Yuan, L Luan, T Andl, X Feng, B Jiao, M Xu, M Plikus, X Dai, C Lengner, W Cui, F Ren, JW Shuai, S Millar, and Z Yu. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nature Communications,2017, 8: 1036
2. Y Tian, X Ma, C Lv, X Sheng, X Li, R Zhao, Y Song, T Andl, M Plikus, J Sun, F Ren, JW Shuai, C Lengner, W Cui, Z Yu. Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis. ELife. 2017, 6: e29538.
3. Yuan Chen, Hong Qi, Xiang Li, Meichun Cai, Xingqiang Chen, Wen Liu, and Jianwei Shuai. Suppressing effect of Ca2+ blips on puff amplitudes by inhibiting channels to prevent recovery. Phys. Rev. E 2016, 94: 022411
4. Xing-Xing Wu and Jianwei Shuai*, Effects of extracellular potassium diffusion on electrically coupled neuron networks, Physical Review E 91(2015) 022712
5. Hong Qi, Linxi Li and Jianwei Shuai, Optimal microdomain corsstalk between endoplasmic reticulum and mitochondria for Ca2+ oscillations, Scientific Reports 5 (2015) 7984 1-11
6. S Ruediger, P Jung and JW Shuai. Termination of Ca2+ release for clustered IP3R channels. PLoS Computational Biology 8 (2012) e1002485 1-13
7. S Rüdiger, J W Shuai* and IM Sokolov. Law of mass action, detailed balance, and the modeling of calcium puffs. Physical Review Letters, 105 (2010) 048103 1-4
8. J W Shuai and P Jung. Entropically enhanced excitability in small systems. Physical Review Letters, 95: 114501 1-4 (2005)
9. J W Shuai and P Jung. Optimal ion channel clustering for intracellular calcium signaling. Proceedings of the National Academy of Sciences of USA, 100: 506-510 (2003)
10. J W Shuai and P Jung. Optimal Intracellular Calcium Signaling. Physical Review Letters, 88: 68102 1-4 (2002)
科研基金及项目 (1)XMU Mingjiang Distinguished Professor Foundation of Fujian Province  
        Computing biophysics  
(2007 – 2010)  
(2)The National Natural Science Foundation of China  
The stochastic dynamics of multiple calcium signal  
NSFC 10775114  
(2008 – 2010)  
(3)The Science and Technology Foundation of Ministry of Education of China  
Simulation of intercellular calcium waves in glia cells  
CME Key grant 108075  
(2008 – 2010)  
(4)National Institutes of Health  Foundation of USA (Co-PI)  
Multi-scale observation and modelling of IP3/Ca signalling  
Grant No.:2R0lGM065830-06A1  
PI: John E. Pearson, Los Alamos Nat Lab  
Co-PI: Ian Parker, University of California, Irvine  
           Kevin Foskett, University of Pennsylvania  
           Don-On Daniel Mak, University of Pennsylvania  
           Jianwei Shuai, Xiamen University  
NIH GM65830  
(2009-2012)  
(5)The National Natural Science Foundation of China  
The interaction between neuronal action potential and intracellular calcium signal  
NSFC 30970970  
(2010 – 2012)  
(6)Specialized Research Fund for the Doctoral Program of Higher Education  
Modelling of calcium diffusion in cellular nanotube  
SRFDP 20090121110028  
(2010 – 2012)  
(7)China National Funds for Distinguished Young Scientists  
Computing Biophysics  
(2012-2015)  
(8)The Funds for the Leading Talents of Fujian Province  
(2013-2015)
任教课程 Introduction of Biophysics
招生方向 荣誉奖励