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陈虎

陈虎的头像

个人信息

职称
教授
Email
chenhu@xmu.edu.cn
办公室
厦门大学海韵园物理机电航空大楼310
研究领域
物理系教授,博士生导师
  • 单分子生物物理实验(单分子操纵与荧光)与理论(分子建模与模拟)
  • 蛋白质的力学响应,蛋白质去折叠与折叠动力学
  • 蛋白质与核酸的相互作用

 热忱欢迎对单分子生物物理感兴趣的同学报考博士或硕士研究生。因为交叉学科的特点,具有物理、生物、化学、电子等背景的研究生都欢迎报考。

同时欢迎有兴趣的本科生参与科学研究。

个人简历
  • 19939-19987月:清华大学物理系,自动化系,北京,中国,理科学士(应用物理),工科学士(计算机应用)
  • 1998 9-20027月:清华大学高等研究中心,北京,中国,博士(理论物理)
  • 20029-20052月:新加坡国立大学民用工程系,SMF-Post Doctoral Research Fellow
  • 20053-20061月:新加坡国立大学民用工程系,Research Fellow
  • 20062-20097月:新加坡国立大学物理系,Research Fellow
  • 20098-20136月:新加坡国立大学力学生物研究所,Research Fellow
在研基金
  • 中央高校基本科研业务费(2013-2015
  • 国家自然科学基金面上项目(2015-2018)(2016-2019)
发表文章
Yuan, G., S. Le, M. Yao, H. Qian, X. Zhou, J. Yan, and H. Chen. 2017. Elasticity of the Transition State Leading to an Unexpected Mechanical Stabilization of Titin Immunoglobulin Domains. Angew. Chem. Int. Ed. Engl. 56:5490-5493.
 
Liu, C., W. L. Zhai, H. Gong, Y. Liu, and H. Chen. 2017. Effect of fluoride ion on the stability of DNA hairpin. Chem. Phys. Lett. 678:35-39.
 
Fan, Y.-T., X.-Y. Li, Y. Liu, and H. Chen. 2017. Effect of temperature on the topological states of circular DNA. Communications in theoretical physics.
 
钱辉, 陈虎, and 严洁. 2016. 软物质实验方法前沿:单分子操控技术. 物理学报 65:188706.
 
Yang, Z. J., G. H. Yuan, W. L. Zhai, J. Yan, and H. Chen. 2016. The kinetics of force-dependent hybridization and strand-peeling of short DNA fragments. Sci. China-Phys. Mech. Astron. 59:680013.
 
Yao, M., H. Chen, and J. Yan. 2015. Thermodynamics of force-dependent folding and unfolding of small protein and nucleic acids structures. Integrative Biology 7:1154-1160.
 
Cong, P., L. Dai, H. Chen, J. R. van der Maarel, P. S. Doyle, and J. Yan. 2015. Revisiting the Anomalous Bending Elasticity of Sharply Bent DNA. Biophys. J. 109:2338-2351.
 
Chen, H., G. Yuan, R. S. Winardhi, M. Yao, I. Popa, J. M. Fernandez, and J. Yan. 2015. Dynamics of Equilibrium Folding and Unfolding Transitions of Titin Immunoglobulin Domain under Constant Forces. J. Am. Chem. Soc. 137:3540-3546.
 
Zhang, X. H., Y. Y. Qu, H. Chen, I. Rouzina, S. L. Zhang, P. S. Doyle, and J. Yan. 2014. Interconversion between Three Overstretched DNA Structures. J. Am. Chem. Soc. 136:16073-16080.
 
Yao, M., B. T. Goult, H. Chen, P. Cong, M. P. Sheetz, and J. Yan. 2014. Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation. Sci Rep 4:4610.
 
Xu, Y., H. Chen, Y. J. Qu, A. K. Efremov, M. Li, Z. C. Ouyang, D. S. Liu, and J. Yan. 2014. Mechano-chemical selections of two competitive unfolding pathways of a single DNA i-motif. Chinese Physics B 23:068702.
 
Le, S., H. Chen, X. Zhang, J. Chen, K. N. Patil, K. Muniyappa, and J. Yan. 2014. Mechanical force antagonizes the inhibitory effects of RecX on RecA filament formation in Mycobacterium tuberculosis. Nucleic Acids Res. 42:11992-11999.
 
Zhang, X., H. Chen, S. Le, I. Rouzina, P. S. Doyle, and J. Yan. 2013. Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry. Proc. Natl. Acad. Sci. U. S. A. 110:3865-3870.
 
Le, S., H. Chen, P. Cong, J. Lin, P. Droge, and J. Yan. 2013. Mechanosensing of DNA bending in a single specific protein-DNA complex. Sci Rep 3:3508.
 
Fu, H., S. Le, H. Chen, K. Muniyappa, and J. Yan. 2013. Force and ATP hydrolysis dependent regulation of RecA nucleoprotein filament by single-stranded DNA binding protein. Nucleic Acids Res. 41:924-932.
 
Chen, H., S. Chandrasekar, M. P. Sheetz, T. P. Stossel, F. Nakamura, and J. Yan. 2013. Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function. Sci Rep 3:1642.
 
Zhang, X., H. Chen, H. Fu, P. S. Doyle, and J. Yan. 2012. Two distinct overstretched DNA structures revealed by single-molecule thermodynamics measurements. Proc. Natl. Acad. Sci. U. S. A. 109:8103-8108.
 
Lin, J., H. Chen, P. Droge, and J. Yan. 2012. Physical organization of DNA by multiple non-specific DNA-binding modes of integration host factor (IHF). PLoS One 7:e49885.
 
Fu, H., H. Chen, X. Zhang, Y. Qu, J. F. Marko, and J. Yan. 2011. Transition dynamics and selection of the distinct S-DNA and strand unpeeling modes of double helix overstretching. Nucleic Acids Res. 39:3473-3481 (co-first author).
 
Chen, H., X. Zhu, P. Cong, M. P. Sheetz, F. Nakamura, and J. Yan. 2011. Differential mechanical stability of filamin A rod segments. Biophys. J. 101:1231-1237.
 
Chen, H., H. Fu, X. Zhu, P. Cong, F. Nakamura, and J. Yan. 2011. Improved high-force magnetic tweezers for stretching and refolding of proteins and short DNA. Biophys. J. 100:517-523.
 
Liu, Y., J. Wu, H. Chen, C. L. Hew, and J. Yan. 2010. DNA condensates organized by the capsid protein VP15 in White Spot Syndrome Virus. Virology 408:197-203.
 
Liu, Y., H. Chen, L. J. Kenney, and J. Yan. 2010. A divalent switch drives H-NS/DNA-binding conformations between stiffening and bridging modes. Genes Dev. 24:339-344 (co-first author).
 
Fu, W. B., H. Chen, M. Li, and J. Yan. 2010. Kinetics of Single DNA Compaction by Hexaammine Cobalt Chloride. J. Comput. Theor. Nanosci. 7:213-217.
 
Fu, H. X., H. Chen, J. Yan, and C. T. Lim. 2010. Salt Solution Effects on Overstretching Transitions of DNA Molecules. J. Comput. Theor. Nanosci. 7:1272-1278.
 
Fu, H., H. Chen, J. F. Marko, and J. Yan. 2010. Two distinct overstretched DNA states. Nucleic Acids Res. 38:5594-5600.
 
Chen, H., H. X. Fu, Z. Zhou, and J. Yan. 2010. Non-harmonic DNA bending elasticity is revealed by statistics of DNA minicircle shapes. International Journal of Modern Physics B 24:5475-5485.
 
Fu, H., H. Chen, C. G. Koh, and C. T. Lim. 2009. Effects of magnesium salt concentrations on B-DNA overstretching transition. Eur Phys J E Soft Matter 29:45-49.
 
Chen, H., Y. Liu, Z. Zhou, L. Hu, Z. C. Ou-Yang, and J. Yan. 2009. Temperature dependence of circular DNA topological states. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 79:041926.
 
Chen, H., and J. Yan. 2008. Effects of kink and flexible hinge defects on mechanical responses of short double-stranded DNA molecules. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 77:041907.
 
Chen, H., H. X. Fu, and C. G. Koh. 2008. Sequence-Dependent Unpeeling Dynamics of Stretched DNA Double Helix. J. Comput. Theor. Nanosci. 5:1381-1386.
 
Fu, H. X., C. G. Koh, H. Chen, and C. T. Lim. 2007. Experimental and numerical studies on B-DNA overstretching transition in presence of sodium ions at physiological temperature. In Nanoscience and Technology, Pts 1 and 2. C. Bai, S. Xie, and X. Zhu, editors. 1093-1096.
 
Bao, Q., H. Chen, Y. Liu, J. Yan, P. Droge, and C. A. Davey. 2007. A divalent metal-mediated switch controlling protein-induced DNA bending. J. Mol. Biol. 367:731-740.
 
Fu, H. X., C. G. Koh, and H. Chen. 2005. Ionic effects on overstretching transition of B-DNA. European Physical Journal E 17:231-235.
 
Chen, H., C. G. Koh, and C. Y. Liaw. 2005. Accessibility of compact structures and prion-like protein folding property. Mod. Phys. Lett. B 19:1241-1252.
 
Zhou, X., H. Chen, and M. Iwamoto. 2004. Orientation orders of small anisotropic molecules in confinement. In Slow Dynamics in Complex Systems. M. Tokuyama, and I. Oppenheim, editors. 170-171.
 
Zhou, X., H. Chen, and M. Iwamoto. 2004. Orientational order in binary mixtures of hard Gaussian overlap molecules. J. Chem. Phys. 120:1832-1836.
 
Zhou, X., H. Chen, and M. Iwamoto. 2004. Orientational orders of small anisotropic molecules confined in slit pores. J. Chem. Phys. 120:5322-5326.
 
Chen, H., X. Zhou, C. Y. Liaw, and C. G. Koh. 2004. Kinetic analysis of protein folding lattice models. Mod. Phys. Lett. B 18:163-172.
 
Zhou, X., H. Chen, and M. Iwamoto. 2002. Nonunique steady states in the disordered harmonic chain. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 66:061202.
 
Chen, H., X. Zhou, and Z. C. Ou-Yang. 2002. Classification of amino acids based on statistical results of known structures and cooperativity of protein folding. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 65:061907.
 
Zhou, X., H. Chen, J. J. Zhou, and Z. C. Ou-Yang. 2001. The structure relaxation of carbon nanotube. Physica B 304:86-90.
 
Zhou, X., H. Chen, and Z. C. Ou-Yang. 2001. Can electric field induced energy gaps in metallic carbon nanotubes? Journal of Physics-Condensed Matter 13:L635-L640.
 
Chen, H., X. Zhou, and Z. C. Ou-Yang. 2001. Difference between "proteinlike" and "nonproteinlike" heteropolymers. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 63:031913.
 
Chen, H., X. Zhou, and Z. C. Ou-Yang. 2001. Secondary-structure-favored hydrophobic-polar lattice model of protein folding. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 64:041905.
 
任教课程
  • 大学物理(大一)
  • Introduction to Biophysics(大三)
  • 单分子生物物理(研究生)

历史

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4 年 14 周